The genesis of Aither Chemicals began in 2010 as an effort to evaluate the utilization of unique, demonstrated technologies to create value added chemicals from ethane. Throughout 2010, a team of highly experienced technical and management staff worked to evaluate the opportunity created by tremendous supplies of ethane coming from the wet natural gas in shale plays. As a result of this evaluation and additional technical work, Aither was officially formed in 2010.

In 2011, Aither hired a leadership team and, later that year, Aither attracted early stage investment and partners, including the INNOVA Commercialization Group, the West Virginia Jobs Investment Trust, and TechConnect West Virginia. In addition, Aither began to put into place a variety of industry and other partnerships and relationships. In 2012, the Renewable Manufacturing Gateway (RMG) joined with Aither to build chemical plants in the tri-state region of West Virginia, Ohio and Pennsylvania.